Transcranial Bipolar Direct Current Stimulation of the Frontoparietal Cortex Reduces Ketamine-Induced Oscillopathies: A Pilot Study in the Sedated Rat
Caroline Lahogue, Didier Pinault
arXiv Preprint Archive October 13, 2020 preprint
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical experimental study Pilot study |
|---|---|
| Population | Sedated adult rats treated with ketamine |
| Intervention | Ketamine |
| Duration | 5-minute stimulation |
| Topics | Esketamine Ketamine |
| Keywords | Q-bio.nc |
| Key findings | A 5-minute unilateral frontoparietal anodal tDCS (under +1 mA) immediately and rapidly reduced ketamine-induced oscillopathies in the bilateral parietal cortex, with a significant intensity-effect relationship and a duration effect. The authors present these preliminary neurophysiological findings as promising for developing a therapeutic proof-of-concept against neuropsychiatric disorders. |
Abstract
Running title: Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies.Abstract: During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies). Neural oscillations are electro-biomarkers of the connectivity state within systems. A single systemic administration of ketamine, a non-competitive NMDA glutamate receptor antagonist, transiently reproduces the oscillopathies with a clinical picture reminiscent of the psychosis prodrome. This acute pharmacological model may help the research and development of innovative treatments against the psychotic transition. Transcranial electrical stimulation is recognized as an appropriate non-invasive therapeutic modality since it can increase cognitive performance and modulate neural oscillations with little or no side effects. Therefore, our objective was to set up, in the sedated adult rat, a stimulation method able to normalize the ketamine-induced oscillopathies. Unilateral transcranial frontoparietal anodal stimulation by direct current (<+1 mA) was applied in ketamine-treated rats. A concomitant electroencephalographic recording of the parietal cortex measured the stimulation effects on its spontaneously-occurring oscillations. A 5-min bipolar anodal tDCS immediately and quickly reduced, significantly with an intensity-effect relationship, the ketamine-induced oscillopathies at least in the bilateral parietal cortex. A duration effect was also recorded. These preliminary neurophysiological findings are promising for developing a therapeutic proof-of-concept against neuropsychiatric disorders.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |