A characteristic effect of hallucinogens on investigatory responding in rats.
Mark A. Geyer, Roger K. Light, Gary J. Rose, L R Petersen, D D Horwitt, L M Adams, Richard L. Hawkins
Psychopharmacology September 1979 DOI: 10.1007/bf00491975 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | LSD N N-dimethyltryptamine psilocin mescaline DOM apomorphine |
| Key points | Hallucinogens including LSD, N,N-dimethyltryptamine, psilocin, mescaline, and DOM disrupted the temporal distribution of investigatory responses in rats on a hole-board, whereas DOM congeners inactive in humans had no significant effects. Of other psychoactive drugs tested, only apomorphine produced a similar effect. The authors propose this behavioral measure as a potential animal model for common hallucinogen effects. |
Abstract
The disruption of the temporal distribution of investigatory responses by rats in a novel hole-board following lysergic acid diethylamide-25 (LSD), as described in a companion paper (Geyer and Light, 1979), was found to be a characteristic effect of a variety of hallucinogens. Similar effects were produced by indoleamine hallucinogens, such as LSD, N,N-dimethyltryptamine, and psilocin, and by phenylethylamine hallucinogens, such as mescaline or 2,5-dimethoxy-4-methylamphetamine (DOM). Congeners of DOM that are inactive in humans had no significant effects. Furthermore, of a variety of other psychoactive drugs tested, only apomorphine produced an effect similar to that of the hallucinogens. These results suggest that a simple behavioral measure of exploration in a hole-board may provide a useful animal model with which to examine the common effects of hallucinogens.
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- The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology August 1, 2015
- Psilocybin – Summary of knowledge and new perspectives European Neuropsychopharmacology December 17, 2013
- Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice Journal of Psychopharmacology December 8, 2010
- Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2012
and 31 more in the library
Cites 4
- The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle. Journal of Pharmacology and Experimental Therapeutics December 1, 1978
- Psychotomimetic phenylisopropylamines. 5. 4-Alkyl-2,5-dimethoxyphenylisopropylamines Journal of Medicinal Chemistry December 1, 1975
- Comparative effects of hallucinogenic drugs on rotational behavior in rats with unilateral 6-hydroxydopamine lesions. European Journal of Pharmacology July 15, 1977
- Effects of N,N-dimethyltryptamine on behavioural habituation in the rat. Pharmacology, Biochemistry, and Behavior February 1977