Effects of N,N-dimethyltryptamine on behavioural habituation in the rat.
S E File
Pharmacology, Biochemistry, and Behavior February 1977 DOI: 10.1016/0091-3057(77)90067-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | N |
| Dose | 2 and 4 mg/kg |
| Duration | 24-hr retention |
| Topics | 5-MeO-DMT DMT |
| Key findings | DMT at 2 and 4 mg/kg prevented 24-hour retention of habituation of exploration, and impaired both the rate of habituation to a tone and its 24-hour retention, without reducing the initial distraction to the tone. The 4 mg/kg dose so profoundly reduced exploration that habituation rate could not be assessed. |
Abstract
The processes involved in habituation and the various ways drugs might affect habituation are discussed. Exploration was measured in a holehoard and N,N-Dimethyltryptamine (DMT, 4 mg/kg) profoundly reduced the level of exploration, precluding any conclusions about the rate of habituation with this dose. However, both 2 and 4 mg/kg doses prevented the 24-hr retention of habituation of exploration. DMT (2 and 4 mg/kg) did not reduce the initial distraction to a tone stimulus, but the rate of habituation and its 24-hr retention was impaired.
Comparable studies
Other preclinical and animal studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Mice and rats | 2006 | Preclinical study | |
| Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Rats and transfected fibroblasts | 1998 | Experimental study | |
| Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat Intact rats and rats depleted of monoamines with reserpine | 1985 | Experimental study |
Citations in the library
Cited by 4
- Chronic, Intermittent Microdoses of the Psychedelic N , N -Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents ACS Chemical Neuroscience March 4, 2019
- A single administration of the hallucinogen, 4-acetoxy-dimethyltryptamine, prevents the shift to a drug-dependent state and the expression of withdrawal aversions in rodents. European Journal of Neuroscience June 1, 2017
- Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats Psychopharmacology July 1, 2009
- A characteristic effect of hallucinogens on investigatory responding in rats. Psychopharmacology September 1979