Effects of N,N-dimethyltryptamine on behavioural habituation in the rat.
Pharmacology, biochemistry, and behavior February 1977 DOI: 10.1016/0091-3057(77)90067-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | N |
| Dose | 2 and 4 mg/kg |
| Duration | 24-hr retention |
| Topics | 5-MeO-DMT DMT |
| Key findings | DMT at 2 and 4 mg/kg prevented 24-hour retention of habituation of exploration, and impaired both the rate of habituation to a tone and its 24-hour retention, without reducing the initial distraction to the tone. The 4 mg/kg dose so profoundly reduced exploration that habituation rate could not be assessed. |
Abstract
The processes involved in habituation and the various ways drugs might affect habituation are discussed. Exploration was measured in a holehoard and N,N-Dimethyltryptamine (DMT, 4 mg/kg) profoundly reduced the level of exploration, precluding any conclusions about the rate of habituation with this dose. However, both 2 and 4 mg/kg doses prevented the 24-hr retention of habituation of exploration. DMT (2 and 4 mg/kg) did not reduce the initial distraction to a tone stimulus, but the rate of habituation and its 24-hr retention was impaired.