Cerebral oedema after ingestion of MDMA (“ecstasy”) and unrestricted intake of water
S M Matthai, J A Sills, D C Davidson, Dionysios Alexandrou
BMJ May 25, 1996 DOI: 10.1136/bmj.312.7042.1359b (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 2 |
| Population | Adolescents who had ingested MDMA |
| Intervention | MDMA |
| Topics | MDMA |
| Citations | 68 |
| Key findings | Two adolescents developed clinical effects from syndrome of inappropriate antidiuretic hormone secretion after taking MDMA. The authors suggest that unrestricted water intake, commonly believed to combat MDMA side effects, may contribute to this dangerous complication when patients are left to sleep it off. |
Abstract
EDITOR,—3, 4-Methylenedioxymethamphetamine (MDMA or “ecstasy”) is a synthetic derivative of amphetamine and a popular recreational drug among young people. It is known to cause severe hyperpyrexia, dehydration, and rhabdomyolysis.1 Unrestricted ingestion of water is commonly believed to be important in combating some of the side effects of ingestion of the drug. We report on two patients who developed clinical effects due to the syndrome of inappropriate secretion of antidiuretic hormone after ingestion of MDMA. These adolescents had been “left to sleep it off” and presented …
Comparable studies
Other case reports and case series on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| 'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA Individuals whose deaths were associated with MDMA or MDEA use | 1987 | Case series | n = 5 |
| Pathology of deaths associated with "ecstasy" and "eve" misuse. Young white men aged 20 to 25 who died after using ring-substituted amphetamines (MDMA... | 1996 | Case series | n = 7 |
| 'Eve' and 'Ecstasy' Individuals who died after using MDMA or MDEA | 1987 | Case series | n = 5 |
| A Method of Conducting Therapeutic Sessions with MDMA Clients with clear therapeutic purpose, excluding those with serious functional... | 1998 | Case study | n = 2 |
| Diversity of Psychopathology Associated with use of 3,4-Methylenedioxymethamphetamine (‘Ecstasy’) Psychiatric patients presenting between 1990 and 1992 whose symptoms developed in the... | 1994 | Case series | n = 13 |
Citations in the library
Cited by 22
- Club drugs: methylenedioxymethamphetamine, flunitrazepam, ketamine hydrochloride, and gamma-hydroxybutyrate American Journal of Health-System Pharmacy June 1, 2002
- Hyponatraemic states following 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') ingestion The Quarterly journal of medicine July 1, 2002
- A Comprehensive Review of MDMA and GHB: Two Common Club Drugs Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy December 1, 2001
- An Exploration of the History and Controversies Surrounding MDMA and MDA Journal of Psychoactive Drugs September 1, 2001
- The effect of 3,4‐methylenedioxymethamphetamine (MDMA, ?ecstasy?) and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus British Journal of Pharmacology February 1, 2002
and 17 more in the library