Hyponatremia associated with 3,4-methylenedioxymethylamphetamine ("Ecstasy") abuse.
Milos N Budisavljevic, Lisa Stewart, Steven A Sahn, David W Ploth
The American journal of the medical sciences August 2003 DOI: 10.1097/00000441-200308000-00006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A young woman who developed hyponatremia after MDMA use |
| Intervention | 5% saline |
| Topics | MDMA |
| Key findings | MDMA use can lead to acute symptomatic hyponatremia, especially in young premenopausal women, with risk of fatal cerebral herniation; treatment with 5% saline led to complete recovery in this case. |
Abstract
We present a case of acute, symptomatic hyponatremia in a young woman that developed after use of 3,4-methylenedioxymethylamphetamine (MDMA), more commonly known as "ecstasy." The patient was treated with 5% saline and had complete recovery. The pathogenesis of MDMA-associated hyponatremia involves excessive water intake and inappropriately elevated antidiuretic hormone (ADH) levels. It seems that young, premenopausal women are at particularly high risk for the development of severe, symptomatic hyponatremia after use of this drug. Review of the literature revealed 4 fatal outcomes from MDMA-associated hyponatremia. All were women and all died from cerebellar tonsillar herniation. We suggest that acute hyponatremia that develops after MDMA use may be a life-threatening condition. Recent recommendation that MDMA users should drink large volumes of water may not be appropriate.