The time-dependent stimulus effects of R(-)-2,5-dimethoxy-4-methamphetamine (DOM): implications for drug-induced stimulus control as a method for the study of hallucinogenic agents.
David Fiorella, P A Palumbo, R A Rabin, Jerrold C Winter
Psychopharmacology May 1995 DOI: 10.1007/bf02246166 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology experiment Peer reviewed |
|---|---|
| Population | Rats trained to discriminate LSD or (-)DOM |
| Interventions | d-LSD (-)DOM |
| Dose | (-)DOM 0.56 mg/kg, (-)DOM 0.8 mg/kg, (-)DOM 0.2 mg/kg, LSD 0.1 mg/kg, LSD 0.32 mg/kg |
| Key findings | The pharmacodynamic properties of LSD and (-)DOM stimulus effects differ in rats: (-)DOM's onset is markedly slower, with substitution for the LSD cue rising from low levels at 15 minutes to 99.5% LSD-appropriate responding at 75 minutes, whereas LSD (0.32 mg/kg) fully substituted for (-)DOM. |
Abstract
The pharmacodynamic characteristics of the stimulus effects of the hallucinogens d-LSD and (-)DOM were investigated in the rat. The stimulus control induced by (-)DOM (0.56 mg/kg) was significantly less stable at the 15-min pretreatment time than at the 75-min pretreatment time. In addition, (-)DOM (0.8 mg/kg) produced a time-dependent substitution for the LSD stimulus in LSD trained subjects (0.1 mg/kg, 15-min pretreatment time). As pretreatment times were increased, the substitution of (-)DOM (0.8 mg/kg) for the LSD stimulus increased, culminating in a maximal level of 99.5% LSD-appropriate responding at the 75-min pre-treatment time. A dose-response relationship for the substitution of (-)DOM (75-min pretreatment time) for the LSD stimulus, indicated that 0.2 mg/kg (-)DOM was the minimum dose which elicited greater than 90% LSD-appropriate responding. LSD (0.32 mg/kg, 15-min pretreatment time) fully substituted for (-)DOM in the (-)DOM trained subjects (0.56 mg/kg, 75-min pretreatment time). These findings suggest that the pharmacodynamic parameters of d-LSD and (-)DOM-induced stimulus control differ. The time of onset for the stimulus effects of (-)DOM is markedly longer than that of LSD in the rat.
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- Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors. Psychopharmacology November 1, 2008
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- Neuropharmacological reassessment of the discriminative stimulus properties ofd-lysergic acid diethylamide (LSD) Psychopharmacology 1987
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- Stimulus effects of ibogaine in rats trained with yohimbine, DOM, or LSD. Pharmacology, Biochemistry, and Behavior December 1, 1992
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