Hallucinogenic Drugs in Psychiatric Research and Treatment Perspectives and Prospects
The Journal of Nervous and Mental Disease March 1, 1995 DOI: 10.1097/00005053-199503000-00002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Citations | 90 |
| Key findings | The authors argue that past human hallucinogen research with LSD and related compounds, involving thousands of patients and control subjects, was associated with acceptable safety under careful screening, supervision, and follow-up, and yielded data on psychopharmacology, psychosis overlap, and psychotherapeutic efficacy. They contend that renewed research should use state-of-the-art methods and explicitly address training and supervision. |
Abstract
Clinical research with hallucinogens has resumed after a generation's hiatus. To place these new studies in context, this article reviews the history of hallucinogens' use and abuse, discusses their pharmacological properties, and highlights previous human studies. Research with lysergic acid diethylamide and related hallucinogens with thousands of patients and control subjects was associated with acceptable safety when subjects were carefully screened, supervised, and followed up. Data were generated regarding hallucinogens' psychopharmacology, overlap with endogenous psychoses, and psychotherapeutic efficacy. Current American and European studies emphasize systematic psychopharmacology, in addition to psychotherapy protocols. Human hallucinogen research will help define unique mind-brain interfaces, and provide mechanistic hypotheses and treatment options for psychiatric disorders. It is critical that human hallucinogen research in the 1990s make use of state of the art methodologies, or consensually define when modifications are required. Training and supervisory issues also must be explicitly addressed.
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- Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up. Journal of Substance Abuse Treatment December 1, 2002
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