Capgras syndrome induced by Ketamine in a Healthy Subject

Philip R. Corlett; D. D’Souza; J. Krystal

doi:10.1016/j.biopsych.2010.02.015

Capgras syndrome induced by Ketamine in a Healthy Subject

Philip R. Corlett, D. D’Souza, J. Krystal

Biological Psychiatry April 10, 2010 DOI: 10.1016/j.biopsych.2010.02.015 (opens in new tab)

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Study at a glance

AI-extracted from the abstract

Characteristics	Case study Case report Peer reviewed
Sample size	1
Population	A healthy subject
Intervention	Ketamine
Topics	Esketamine Ketamine
Key findings	Ketamine induced Capgras syndrome in a healthy subject, which the authors believe is the first report of delusion-like misidentification following controlled administration of a psychotomimetic drug. They propose that ketamine's mechanisms may contribute to endogenous misidentification syndromes.

Abstract

We would like to report a case of Capgras syndrome in a healthy subject, which was induced by ketamine, [an antagonist of the N-methyl D-aspartate (NMDA) subtype of glutamate receptors]. We believe this is the first report of delusion-like misidentification following controlled administration of a psychotomimetic drug, raising the possibility that the neurochemical and cognitive mechanisms through which ketamine acts may also contribute to endogenous misidentification syndromes.

Comparable studies

Other case reports and case series on ketamine, most cited first.

Study	Year	Design	Participants
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? Young recreational abusers of street-ketamine in Hong Kong referred to urology units	2008	Retrospective case series	n = 59
Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood. A patient with treatment-resistant depression and comorbid generalized anxiety...	2025	Case report	n = 1
Treatment of compulsive behaviour in eating disorders with intermittent ketamine infusions Chronic and treatment-resistant eating disorder patients	1998	Case series	n = 15
Oral Administration of the NMDA Receptor Antagonist S-Ketamine as Add-On Therapy of Depression: A Case Series Four depressed patients taking standard antidepressants	2009	Case series	n = 4
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression Patients with enduring eating disorders and treatment-resistant depression	2021	Case series	n = 4

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