Psycho-endocrine-immune response to mindfulness-based stress reduction in individuals infected with the human immunodeficiency virus: a quasiexperimental study.
F Patrick Robinson, Herbert L Mathews, Linda Witek Janusek
The Journal of Alternative and Complementary Medicine October 2003 DOI: 10.1089/107555303322524535 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Quasiexperimental, nonrandomized Peer reviewed |
|---|---|
| Population | Individuals infected with HIV |
| Intervention | Mindfulness-Based Stress Reduction (MBSR) |
| Duration | 8-week intervention |
| Topics | Meditation |
| Key findings | Natural killer cell activity and number increased significantly in the MBSR group compared to the comparison group, while no significant changes or differences were found for psychological, endocrine, or functional health variables. |
Abstract
The purpose of this study was to examine the effects of a structured, 8-week, Mindfulness-Based Stress Reduction (MBSR) program on perceived stress, mood, endocrine function, immunity, and functional health outcomes in individuals infected with the human immunodeficiency virus (HIV). This study used a quasiexperimental, nonrandomized design. Subjects were specifically recruited (nonrandom) for intervention (MBSR) or comparison group. Data were collected at pretest and post-test in the MBSR group and at matched times in the comparison group. t Tests where performed to determine within-group changes and between-group differences. Natural killer cell activity and number increased significantly in the MBSR group compared to the comparison group. No significant changes or differences were found for psychological, endocrine, or functional health variables. These results provide tentative evidence that MBSR may assist in improving immunity in individuals infected with HIV.
Comparable studies
Other non-randomized and open-label trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Mindfulness-Based Stress Reduction in Relation to Quality of Life, Mood, Symptoms of Stress, and Immune Parameters in Breast and Prostate Cancer Outpatients Early-stage breast and prostate cancer patients | 2003 | Pre-post intervention study | n = 59 |
| Exploring self‐compassion and empathy in the context of mindfulness‐based stress reduction (MBSR) Community sample | 2010 | Pre-post intervention study | |
| Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students Second-year medical students | 2003 | Prospective nonrandomized cohort-controlled study | n = 302 |
| Intensive meditation training, immune cell telomerase activity, and psychological mediators. Retreat participants and matched controls | 2011 | Controlled trial with wait-list control group | n = 60 |
| The Effectiveness of Mindfulness Training for Children with ADHD and Mindful Parenting for their Parents Children aged 8-12 with ADHD and their parents | 2011 | Within-group waitlist controlled trial | n = 22 |
Citations in the library
Cited by 51
- A systematic review of neurobiological and clinical features of mindfulness meditations Psychological Medicine November 27, 2009
- How long does a mindfulness‐based stress reduction program need to be? A review of class contact hours and effect sizes for psychological distress Journal of Clinical Psychology March 23, 2009
- Effects of Mindfulness-Based Stress Reduction Intervention on Psychological Well-being and Quality of Life: Is Increased Mindfulness Indeed the Mechanism? Annals of Behavioral Medicine June 1, 2008
- Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: Results of a randomized clinical trial Arthritis Care & Research January 31, 2007
- Short-term autonomic and cardiovascular effects of mindfulness body scan meditation Annals of Behavioral Medicine November 15, 2006
and 46 more in the library
Cites 10
- Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology 2000
- Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders American Journal of Psychiatry July 1, 1992
- A Randomized, Wait-List Controlled Clinical Trial: The Effect of a Mindfulness Meditation-Based Stress Reduction Program on Mood and Symptoms of Stress in Cancer Outpatients Psychosomatic Medicine September 1, 2000
- What Do We Really Know About Mindfulness-Based Stress Reduction? Psychosomatic Medicine 2002
- Stress Reduction through Mindfulness Meditation Psychotherapy and Psychosomatics February 18, 2010
and 5 more in the library