The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOM.
Jerrold C Winter, Justin R Eckler, Mireille M Doat, R A Rabin
Pharmacology, biochemistry, and behavior December 2002 DOI: 10.1016/s0091-3057(02)00959-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 11 |
| Population | Rats |
| Interventions | Fluoxetine Citalopram DOM |
| Dose | DOM 0.56 mg/kg; fluoxetine and citalopram doses not specified |
| Duration | 10-day treatment period |
| Key findings | Acute fluoxetine and citalopram potentiated the stimulus effects of DOM in rats, and this potentiation persisted unchanged after 10 days of SSRI treatment, indicating that adaptive changes from subchronic SSRI treatment do not affect this potentiation. |
Abstract
Previous reports from our laboratory have provided evidence that acute, i.e., concurrent, treatment with selective serotonin reuptake inhibitors (SSRIs) augments the stimulus effects of indoleamine and phenethylamine hallucinogens in the rat. In the present investigation, the acute effects of fluoxetine and citalopram on stimulus control induced by (-)-2,5-dimethoxy-4-methylamphetamine (DOM) were compared with those following subchronic, i.e., 10-day treatment with the SSRIs. Stimulus control was established using DOM (0.56 mg/kg; 75-min pretreatment time) in a group of 11 rats. A two-lever, fixed ratio 10, positively reinforced task with saline controls was employed. The effects of a range of doses of DOM when given alone were compared with those following both acute and subchronic pretreatment with fluoxetine and citalopram in combination with DOM. It was found that acute administration of fluoxetine and citalopram potentiated the stimulus effects of DOM. Furthermore, it was observed that the degree of potentiation was not diminished by treatment with either fluoxetine or citalopram for a period of 10 days. It is concluded that whatever adaptive changes may take place in response to a 10-day period of treatment with either citalopram or fluoxetine, these adaptations are independent of the mechanisms responsible for the potentiation of the stimulus effects of DOM by the SSRIs.