The effect of chronic treatment with clozapine and haloperidol on stimulus control by DOM.
Mireille M Doat, Richard A. Rabin, Jerrold C Winter
The International Journal of Neuropsychopharmacology June 2002 DOI: 10.1017/s1461145702002882 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal drug-discrimination study Peer reviewed |
|---|---|
| Population | Rats trained to discriminate [-]-DOM from vehicle |
| Interventions | Clozapine Haloperidol |
| Dose | clozapine 25 mg/kg.d; haloperidol 1 mg/kg.d; [-]-DOM 0.3 mg/kg |
| Duration | 7 days of antipsychotic treatment; [-]-DOM discrimination training with 75 min pre-treatment time |
| Key points | Chronic clozapine (25 mg/kg per day for 7 days) reduced [-]-DOM-appropriate responding by 57% in rats trained to discriminate [-]-DOM, whereas haloperidol (1 mg/kg per day for 7 days) had no effect. The authors argue that decreased 5-HT2A receptor-mediated activity is a unique in-vivo effect of clozapine and might account for some clinical differences between atypical and typical antipsychotics. |
Abstract
The present study investigated the effects of chronic treatment with the atypical antipsychotic, clozapine, or the typical antipsychotic, haloperidol, on the stimulus properties of 2,5-dimethoxy-4-methylamphetamine ([-]-DOM) in rats trained to discriminate [-]-DOM (0.3 mg/kg; 75 min pre-treatment time) from vehicle. As compared with control values, treatment with clozapine (25 mg/kg.d) for 7 d caused a statistically significant 57% reduction in [-]-DOM-appropriate responding. Unlike clozapine, treatment with haloperidol (1 mg/kg.d) for 7 d did not affect the stimulus properties of [-]-DOM. These findings demonstrate that a functionally significant decrease in 5-HT2A receptor-mediated activity is a unique component of the in-vivo response to chronic treatment with clozapine but not haloperidol and, therefore, might account for some of the clinical differences associated with atypical antipsychotics.
Citations in the library
Cited by 2
- Effects of clozapine and 2,5-dimethoxy-4-methylamphetamine [DOM] on 5-HT2A receptor expression in discrete brain areas. Pharmacology, Biochemistry, and Behavior August 1, 2005
- The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOM. Pharmacology, Biochemistry, and Behavior December 2002