Role of the serotonin 5-HT(2A) receptor in learning.
J. Harvey
Learning & Memory September 1, 2003 preprint DOI: 10.1101/lm.60803 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review |
|---|---|
| Topics | Serotonin |
| Key findings | Argues that the 5-HT2A receptor exhibits constitutive activity, with agonists like LSD enhancing associative learning, neutral antagonists having no effect, and inverse agonists like MDL11,939, ritanserin, and mianserin retarding learning through actions at this receptor. |
Abstract
This study reviews the role of the serotonin 5-HT2A receptor in learning as measured by the acquisition of the rabbit's classically conditioning nictitating membrane response, a component of the eyeblink response. Agonists at the 5-HT2A receptor including LSD (d-lysergic acid diethylamide) enhanced associative learning at doses that produce cognitive effects in humans. Some antagonists such as BOL (d-bromolysergic acid diethylamide), LY53,857, and ketanserin acted as neutral antagonists in that they had no effect on learning, whereas others (MDL11,939, ritanserin, and mianserin) acted as inverse agonists in that they retarded learning through an action at the 5-HT2A receptor. These results were placed in the context of what is known concerning the anatomical distribution and electrophysiological effects of 5-HT2A receptor activation in frontal cortex and hippocampus, as well as the role of cortical 5-HT2A receptors in schizophrenia. It was concluded that the 5-HT2A receptor demonstrates constitutive activity, and that variations in this activity can produce profound alterations in cognitive states.
Comparable studies
Other narrative reviews on serotonin, most cited first.
Citations in the library
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- LSD-induced entropic brain activity predicts subsequent personality change. Human Brain Mapping May 6, 2016
- The paradoxical psychological effects of lysergic acid diethylamide (LSD) Psychological Medicine February 5, 2016
- Classical psychedelics for the treatment of depression and anxiety: A systematic review. Journal of Affective Disorders November 1, 2019
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- Altered states: the clinical effects of Ecstasy. Pharmacology & Therapeutics April 2003
and 2 more in the library