Ketamine en esketamine bij bipolaire depressie
Kristin Raj
February 27, 2025 DOI: 10.64239/pi-nl-qt7204 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review |
|---|---|
| Interventions | Ketamine Esketamine |
| Topics | Esketamine Ketamine |
| Key findings | Ketamine and esketamine yield a 40% response rate and 13% remission rate in bipolar depression, with no acute manic switches during intensive treatment but a 30% incidence of hypomanic or manic episodes during maintenance, mostly mild. |
Abstract
Ketamine en esketamine tonen veelbelovende resultaten bij bipolaire depressie: 40% van de patiënten reageert positief op behandeling tweemaal per week. Volledige remissie wordt bereikt bij 13%. Tijdens de intensieve behandelfase traden geen acute manische switches op, maar 30% van de patiënten ervoer een hypomane of manische episode tijdens de onderhoudsfase. De meeste episoden waren licht van aard. Overweeg familieleden te betrekken bij het monitoren van stemmingsveranderingen. Patiënten met een voorgeschiedenis van ernstige manie of rapid cycling zijn mogelijk minder geschikte kandidaten.
Comparable studies
Other narrative reviews on esketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Adults with treatment-resistant depression | 2021 | Review | |
| Long-term safety of ketamine and esketamine in treatment of depression | 2022 | Review | |
| Ketamine, Esketamine, and Arketamine: Their Mechanisms of Action and Applications in the Treatment of Depression and Alleviation of Depressive Symptoms. | 2024 | Review | |
| The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence. | 2023 | Review | |
| Variations in BDNF and Their Role in the Neurotrophic Antidepressant Mechanisms of Ketamine and Esketamine: A Review. Patients with depression | 2024 | Narrative review |