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The Impact of BWM‐T Versus Brief Mindfulness Induction on Stress, Anxiety and Self‐Efficacy in University Students: Immediate and Short‐Term Outcomes of RCT on Psychological Well‐Being and Autonomic Balance

Mauro Cozzolino, Marco Borgese, Giovanna Celia

Brain and Behavior May 1, 2026 DOI: 10.1002/brb3.71471 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Sample size 68
Population University students
Interventions Brain wave modulation technique (BWM-T) brief mindfulness induction
Duration Single 16-minute session, assessments at baseline, immediately after, and 4 hours later
Topics Anxiety Meditation
Keywords Randomized controlled trial Psychological intervention Heart rate variability Analysis of variance Repeated measures design Clinical psychology Differential effects Psychological distress
Key findings A single 16-minute session of either BWM-T or brief mindfulness induction reduced state anxiety and distress and increased self-efficacy, with effects persisting up to 4 hours; only VLF power showed a differential group effect.

Abstract

Background: University students face increasing levels of stress, anxiety, and self-efficacy, which may disrupt autonomic balance. While many mind-body interventions require sustained practice, growing evidence suggests that even a single session can yield immediate benefits. This randomized controlled trial compared the immediate and short-term effects of the brain wave modulation technique (BWM-T) and a brief mindfulness induction on psychological and physiological outcomes in university students.

Methods: 68 students were randomly assigned to either BWM-T or a brief mindfulness induction. State anxiety (STAI-Y1), psychological distress (distress thermometer), generalized self-efficacy scale (GSES), and 5 min heart rate variability (HRV) indices were assessed at baseline (T0), immediately after the session (T1), and 4 h later (T2). Mixed-design ANOVAs with Time (T0, T1, T2) as a within-subject factor and group (BWM-T vs. brief mindfulness induction) as a between-subject factor were conducted, followed by paired-sample t-tests where appropriate.

Results: Across the total sample, significant main effects of Time emerged for state anxiety, distress, and self-efficacy (ps < 0.001), indicating reductions in anxiety and distress and increases in self-efficacy from pre-to post-session that were largely maintained at the 4 h follow-up. No significant time × group interactions were found for psychological outcomes, suggesting comparable trajectories for BWM-T and mindfulness. For HRV indices, a significant time × group interaction was observed only for VLF power. VLF decreased from T0-T1 in the BWM-T group, whereas no systematic changes were detected in the mindfulness group. All other HRV parameters (SDNN, rMSSD, pNN50, LF, HF, LF/HF) remained stable over time, with no differential group effects.

Conclusions: A single 16 min session of either BWM-T or a brief mindfulness induction yielded rapid improvements in self-reported anxiety, distress and GSES in university students, with effects persisting up to 4 h. Physiological effects were limited to a short-lived reduction in VLF power following BWM-T, while other indices of vagally mediated HRV did not change significantly. These findings support the use of brief mind-body practices as feasible tools for acute stress regulation in academic settings, while underscoring the need for larger, adequately powered trials and more comprehensive autonomic assessments.

Comparable studies

Other randomized controlled trials on anxiety, most cited first.

Study Year Design Participants
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Hallucinogen-naïve adults reporting regular participation in religious or spiritual... 2006 Double-blind study n = 36
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer Adults with advanced-stage cancer and anxiety 2010 Double-blind, placebo-controlled study n = 12

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