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Development of a RP-HPLC Method for Separating and Quantifying Muscimol in Different Developmental Stages of the Fungus Amanita muscaria

Emerson León, James Guevara‐Pulido

Journal of Chemistry November 20, 2020 DOI: 10.1155/2020/8859998 (opens in new tab)

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Characteristics Quantitative analytical method development Peer reviewed
Population Amanita muscaria mushrooms at five developmental stages
Keywords Muscimol Amanita Fungus Tardive dyskinesia Metabolite Chromatography Botany Gabaa receptor Biochemistry
Citations 3
Key points The maximum concentration of muscimol (1,210 mg/ml) was found in the young mushroom stage, with concentrations decreasing as the fungus ages.

Abstract

A simple RP-HPLC method was designed for the quantification of muscimol (5-(aminomethyl)-isoxazol-3-ol) present in five aqueous extracts of Amanita muscaria each from a different developmental stage. Results show that the maximum concentration of muscimol (1,210 mg/ml) was found in the young mushroom stage of development. Moreover, it was also found that this concentration progressively decreases as the fungus ages. The developed method is a simple but effective method for the quantification of muscimol, a widely important metabolite for the pharmaceutical industry as a possible treatment for tardive dyskinesia and Parkinson’s disease.

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