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The Intersection of Psychedelics and Sleep: Exploring the Impacts on Sleep Architecture, Dream States, and Therapeutic Implications

Haojiang Zhai, Hongshuang Wang, Haohong Li, Xiaohui Wang

ACS Pharmacology & Translational Science May 15, 2025 DOI: 10.1021/acsptsci.5c00234 (opens in new tab)

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AI-extracted from the abstract
Characteristics Theoretical or philosophical paper Peer reviewed
Topics Dreaming Psilocybin
Keywords Insomnia Psychedelics Profoundly impact Influencing Substances Emerging perspective Improving sleep quality Addressing conditions Alter sleep architecture Vivid dreaming
Citations 3
Key points Argues that psychedelics may alter sleep phases and dreaming, with potential therapeutic applications for sleep disorders, but the area remains underexplored.

Abstract

The interplay between psychedelics, such as psilocybin, lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT), and sleep is an emerging area, but their impact on sleep remains relatively underexplored. This viewpoint provides a perspective on how psychedelics may alter sleep phases, dreaming, and their potential therapeutic applications for sleep disorders.

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