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Association between Decentering and Reductions in Relapse/Recurrence in Mindfulness-Based Cognitive Therapy for Depression in Adults: A Randomized Controlled Trial

Michael Moore, Mark A. Lau, Emily A. P. Haigh, Brandilyn R. Willett, Colin M. Bosma, David M. Fresco

January 31, 2022 DOI: 10.31231/osf.io/mx32f (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial
Sample size 227
Population Formerly depressed individuals
Interventions Mindfulness-based cognitive therapy Relaxation group therapy Treatment-as-usual
Duration 12-month follow-up with assessments at 3, 6, 9, and 12 months post-treatment
Topics Meditation Depression
Keywords Mindfulness-based cognitive therapy Depression economics Relapse prevention Psychotherapist Feeling Clinical psychology Psychological intervention Randomized controlled trial
Citations 2
Key findings Gains in decentering from mid- to post-treatment predicted reductions in depression for MBCT and TAU, but not for RGT, and higher decentering gains were linked to lower relapse rates across groups.

Abstract

Objective: “Decentering” is defined as the ability to observe one’s thoughts and feelings as temporary, objective events in the mind (Safran & Segal, 1990), and is increasingly regarded as a candidate mechanism in mindfulness-based interventions. The current study sought to examine the role of decentering, and other related variables, in the efficacy of Mindfulness-based cognitive therapy (MBCT) as compared to two active comparison conditions.

Method: Formerly depressed individuals (N = 227), randomly assigned to MBCT (n = 74), relaxation group therapy (RGT; n = 77) or treatment-as-usual (TAU; n = 76), completed self-report measures of decentering and symptoms of depression at pre-, mid-, and post-treatment, and relapse was assessed at 3, 6, 9, and 12 months, post-treatment.

Results: With regard to the acute treatment phase, results indicated that, whereas levels of depression increased in both RGT and TAU, MBCT patients remained free from symptom gains. Moreover, gains in decentering from mid- to post-treatment predicted reductions in depression from pre- to post-treatment for MBCT and TAU, but not for RGT. Participants who experienced increases in decentering, measured from mid- to post-treatment, generally evidenced the lowest levels of relapse/recurrence (during the four follow-up assessments), largely irrespective of treatment group. However, results related to change in decentering should be considered exploratory due to small cell sizes among participants who did not experience gains in decentering.Conclusions: Taken together, these results suggest that decentering is a potent mechanism for reduction of relapse in major depression, albeit one that is non-specific to MBCT.

Comparable studies

Other randomized controlled trials on depression, most cited first.

Study Year Design Participants
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Subjects with DSM-IV major depression (treatment resistant) 2006 Randomized, placebo-controlled, double-blind crossover study n = 18
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

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