Disrupting The Resting State: Meta-Analytic Evidence That Mindfulness Training Alters Default Mode Network Connectivity
Hadley Rahrig, David R. Vago, Matthew A. Passarelli, Allison Auten, Nicholas A. Lynn, Kirk Warren Brown
Research Square January 6, 2022 preprint DOI: 10.21203/rs.3.rs-1189676/v1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review and meta-analysis |
|---|---|
| Sample size | 430 |
| Population | Participants in mindfulness training or structurally-equivalent control programs |
| Intervention | mindfulness training |
| Topics | Default mode network Meditation |
| Keywords | Anterior cingulate cortex Meta-analysis Psycinfo Resting State FMRI Publication bias Posterior cingulate Functional connectivity Clinical psychology Medline Cognition |
| Citations | 2 |
| Key findings | Mindfulness training increased resting-state functional connectivity between the salience network and default mode network, specifically between left middle cingulate and posterior cingulate cortex. |
Abstract
Abstract This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We conducted a systematic review and meta-analysis of rsFC as an outcome of mindfulness training (MT) relative to structurally-equivalent programs, with the hypothesis that that MT would increase cross-network connectivity between nodes of the Default Mode Network (DMN), Salience Network (SN), and Frontoparietal Control Network (FPCN) as a mechanism of internally-oriented attentional control. Texts were identified from the databases: MEDLINE/PubMed, ERIC, PSYCINFO, ProQuest, Scopus, and Web of Sciences; and were screened for inclusion based on experimental/quasi-experimental trial design and use of standardized mindfulness-based interventions. RsFC effects were extracted from twelve studies (mindfulness n = 226; control n = 204). Voxel-based meta-analysis revealed significantly greater rsFC (MT > control) between the left middle cingulate ( Hedge’s g = .234, p = 0288, I 2 = 15.87), located within the SN, and the posterior cingulate cortex, a focal hub of the DMN. Egger’s test for publication bias was nonsignificant, bias = 2.17, p = .162. In support of our hypothesis, results suggest that MT targets internetwork (SN-DMN) connectivity implicated in the flexible control of internally-oriented attention.
Comparable studies
Other systematic reviews and meta-analyses on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes | 2015 | Meta-analysis | |
| Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling | 2009 | Meta-analysis | |
| The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis Healthy individuals | 2016 | Systematic review and meta-analysis | |
| Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports. | 2013 | Systematic review with meta-analytic comparison | |
| Default Mode Network Modulation by Psychedelics: A Systematic Review Participants from included studies | 2022 | Systematic review |
Citations in the library
Cited by 2
- Epigenetic, psychological, and EEG changes after a 1-week retreat based on mindfulness and compassion for stress reduction: Study protocol of a cross-over randomized controlled trial medRxiv March 5, 2023
- Epigenetic, psychological, and EEG changes after a 1-week retreat based on mindfulness and compassion for stress reduction in healthy adults: Study protocol of a cross-over randomized controlled trial. PLoS One 2023
Cites 40
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- Mindfulness Interventions Annual Review of Psychology September 30, 2016
- Mind the Hype: A Critical Evaluation and Prescriptive Agenda for Research on Mindfulness and Meditation Perspectives on Psychological Science October 10, 2017
- Meditation experience is associated with differences in default mode network activity and connectivity Proceedings of the National Academy of Sciences November 23, 2011
and 35 more in the library