Rationale, design, and implementation of a clinical trial of a mindfulness-based relapse prevention protocol for the treatment of women with comorbid post traumatic stress disorder and substance use disorder.
Caroline Vrana, Therese K Killeen, Victoria Brant, Jana Mastrogiovanni, Nathaniel L Baker
Contemporary Clinical Trials October 1, 2017 DOI: 10.1016/j.cct.2017.07.024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled pilot trial Pilot study Peer reviewed |
|---|---|
| Population | Women with comorbid PTSD and SUD enrolled in a community-based SUD treatment program |
| Intervention | Mindfulness-based Relapse Prevention (MBRP) |
| Topics | PTSD Addiction Meditation |
| Keywords | Behavioral therapy development Community research Mindfulness-based relapse prevention Sud |
| Key findings | The paper presents the design and methods for a study modifying Mindfulness-based Relapse Prevention to address both PTSD and SUD in women, with plans to revise the manual, pilot the intervention, and conduct a randomized controlled pilot trial. |
Abstract
Comorbid post-traumatic stress disorder (PTSD) and substance use disorders (SUD) commonly co-occur and is associated with a more complex clinical presentation with poorer clinical outcomes when compared with either disorder alone, and untreated PTSD can predict relapse to substance abuse. A number of integrated treatment approaches addressing symptoms of both PTSD and SUD concurrently demonstrate that both disorders can safely and effectively be treated concurrently. However, attrition and SUD relapse rates remain high and there is need to further develop new treatment approaches. Innovative approaches such as mindfulness meditation (MM) successfully used in the treatment of SUD may offer additional benefits for individuals with SUD complicated with PTSD. Specifically, Mindfulness-based Relapse Prevention (MBRP) integrates coping skills from cognitive-behavioral relapse prevention therapy with MM practices, raising awareness of substance use triggers and reactive behavioral patterns, and teaching skillful coping responses. Here we present the design and methods for the "Mindfulness Meditation for the Treatment of Women with comorbid PTSD and SUD" study, a Stage 1b behavioral development study that modifies MBRP treatment to address both PTSD and SUD in a community setting. This study is divided into three parts: revising the existing evidence-based manual, piloting the intervention, and testing the new manual in a randomized controlled pilot trial in women with comorbid PTSD and SUD enrolled in a community-based SUD treatment program.
Comparable studies
Other randomized controlled trials on PTSD, most cited first.
Citations in the library
Cites 10
- Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology 2000
- Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders American Journal of Psychiatry July 1, 1992
- Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials Acta Psychiatrica Scandinavica April 28, 2011
- A PILOT STUDY OF GROUP MINDFULNESS-BASED COGNITIVE THERAPY (MBCT) FOR COMBAT VETERANS WITH POSTTRAUMATIC STRESS DISORDER (PTSD) Depression and Anxiety April 17, 2013
- Mindfulness Meditation, Anxiety Reduction, and Heart Disease Family & Community Health 2003
and 5 more in the library