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Brief Training in Mindfulness Meditation Reduces Symptoms in Patients with a Chronic or Recurrent Lifetime History of Depression: A Randomized Controlled Study

Emilia Winnebeck, Maria Fißler, Matti Gärtner, Paul Chadwick, Thorsten Barnhofer

DOI: 10.31231/osf.io/jy3gs_v1 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial
Sample size 74
Population Acutely depressed patients with a chronic or recurrent lifetime history
Interventions mindfulness-based intervention psycho-educational components and regular rest periods
Topics Depression Meditation
Key findings A brief mindfulness-based intervention reduced depression symptoms more than a control condition in acutely depressed patients with chronic or recurrent depression.

Abstract

Background: Training in mindfulness has been introduced to the treatment of depression as a means of relapse prevention. However, from a stress-buffering perspective, mindfulness techniques would be expected to unfold their beneficial effects particularly in those who are currently suffering from symptoms. This study investigated whether a brief and targeted mindfulness-based intervention can reduce symptoms in acutely depressed patients.Methods: Seventy-four patients with a chronic or recurrent lifetime history were randomly allocated to receive either a brief mindfulness-based intervention (MBI) encompassing three individual sessions and regular home practice or a control condition that combined psycho-educational components and regular rest periods using the same format as the MBI. Self-reported severity of symptoms, mindfulness in every day life, ruminative tendencies and cognitive reactivity were assessed before and after intervention.Results: Patients in the MBI condition showed pronounced and significantly stronger reductions in symptoms than those in the control condition. In the MBI group only, patients showed significant increases in mindfulness, and significant reductions in ruminative tendencies and cognitive reactivity.Conclusions: Findings are in line with a stress-buffering account of mindfulness and suggest that brief targeted mindfulness interventions can help to reduce symptoms in acutely depressed patients with chronic or recurrent lifetime history.

Comparable studies

Other randomized controlled trials on depression, most cited first.

Study Year Design Participants
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Subjects with DSM-IV major depression (treatment resistant) 2006 Randomized, placebo-controlled, double-blind crossover study n = 18
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

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