Default mode network resting-state functional connectivity and event centrality in adult acute trauma survivors.
Amy Z Wang, Carissa W Tomas, Sarah Stevens, Sadie E Larsen, Terri A deRoon-Cassini, Christine L Larson
Scientific Reports May 21, 2026 DOI: 10.1038/s41598-026-51392-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 215 |
| Population | Adult acute traumatic injury survivors recruited from a Level I trauma center |
| Duration | 12-month follow-up |
| Topics | Default mode network PTSD |
| Keywords | Adverse psychological outcomes Event centrality Resting-state functional connectivity Traumatic injury |
| Key findings | Resting-state functional connectivity between the lateral parietal cortex and hippocampus at 2–4 weeks post-injury was significantly associated with event centrality at 12 months, and adverse psychological outcomes mediated this relationship. |
Abstract
Research has identified functional connectivity abnormalities in the default mode network (DMN), a functional brain network theorized to be involved in self-referential processes, among trauma survivors. Event centrality (EC) is an important cognitive component of posttrauma stress disorder (PTSD) development that heavily involves self-referential processing and autobiographical memory. However, the impact of EC in a neuroimaging context remains underexplored. This study investigated the relationships between DMN resting-state functional connectivity (rsFC) and event centrality and the mediating effects of adverse psychological outcomes on DMN rsFC and event centrality among acute traumatic injury survivors. Two hundred and fifteen adult participants were recruited from a Level I trauma center after sustaining a traumatic injury, followed by resting-state fMRI scanned at 2-4 weeks post-injury and self-report questionnaires collected at 2-4 weeks and 3-, 6-, and 12 months post-injury. Event centrality, at 3- and 12-month, was significantly associated with measures of adverse psychological outcomes, and EC at 12-month was significantly associated with the rsFC of two nodes of the DMN: the lateral parietal cortex and hippocampus. In addition, specific adverse psychological outcomes significantly mediated this relationship between rsFC and event centrality. This novel neuroimaging finding suggests potential mechanisms that contribute to increased psychological distress and greater event centrality in traumatic injury recovery.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |