Long‐term benefits of single‐dose psilocybin in depressed patients with cancer

A single 25 mg dose of psilocybin combined with psychotherapy provided long-term relief from depression and anxiety in patients with cancer. Two years after treatment, over half of the 28 patients showed significant reduction in depression, with an average 15-point drop on the Montgomery Asberg Depression Rating Scale, and half maintained that improvement. Nearly half also experienced significant anxiety reduction, averaging a 13.9-point decrease on the Hamilton Anxiety Rating Scale, with 43% sustaining the benefit. The findings indicate a potentially paradigm-changing alternative to standard antidepressants for this population.

Study at a glance

Abstract

Abstract Background Patients with cancer often struggle with depression, which can negatively impact quality of life as well as be challenging to manage. Methods A phase 2 trial was conducted that demonstrated safety, feasibility, and efficacy of a single dose of psilocybin combined with psychological support in a community cancer setting in 30 patients with cancer and a major depressive disorder. Here, efficacy outcomes at 2 years’ follow‐up are reported. Results Of 28 patients, 15 (53.6%) demonstrated significant reduction in depression as measured by the Montgomery Asberg Depression Rating Scale (average, –15.0 points from baseline; p < .001), and 14 (50%) had sustained depression reduction. Thirteen patients (46.4%) experienced significant reduction in anxiety as measured by the Hamilton Anxiety Rating Scale (average, –13.9 points from baseline, p < .001), and 12 (42.9%) had sustained anxiety reduction. Conclusions These findings demonstrate robust antidepressive activity from a single 25 mg dose of psilocybin combined with psychotherapy and suggest a potentially paradigm‐changing alternative to traditional antidepressants requiring further study.