Evaluation of the Trajectory of Depression Severity With Ketamine and Esketamine Treatment in a Clinical Setting
Sina Nikayin, Taeho Greg Rhee, Maria Elena Cunningham, Christina A. de Fontnouvelle, Robert Ostroff, Gerard Sanacora, Samuel T. Wilkinson
JAMA Psychiatry May 11, 2022 DOI: 10.1001/jamapsychiatry.2022.1074 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Comparative analysis Peer reviewed |
|---|---|
| Population | Patients treated with intravenous ketamine or intranasal esketamine in a clinical setting |
| Interventions | Intravenous ketamine Intranasal esketamine |
| Topics | Depression Esketamine Ketamine |
| Keywords | Otorhinolaryngology Neurology Family medicine Depression economics Medline |
| Citations | 43 |
| Key points | Patients treated with intravenous ketamine or intranasal esketamine showed similar trajectories of depression severity. |
Abstract
This comparative analysis examines the trajectory of depression severity among patients treated with intravenous ketamine or intranasal esketamine in a clinical setting.
Citations in the library
Cited by 31
- Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis. JAMA Psychiatry October 19, 2022
- The Antidepressant Actions of Ketamine and its Enantiomers Pharmacology & Therapeutics May 1, 2023
- Personalized use of ketamine and esketamine for treatment-resistant depression. Translational Psychiatry November 29, 2024
- Ketamine and its two enantiomers in anesthesiology and psychiatry: A historical review and future directions Journal of Anesthesia and Translational Medicine July 11, 2024
- Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis. Journal of Affective Disorders July 1, 2024
and 26 more in the library
Cites 3
- Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis Journal of Affective Disorders September 23, 2020
- Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study. Journal of Affective Disorders November 14, 2019
- A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings. Journal of Affective Disorders 2022