Anti-correlated Brain Networks and Self-agency Experience in First-episode Schizophrenia-spectrum Patients. an FMRI Study.
Filip Španiel, Jaroslav Tintěra, Jan Rydlo, Ibrahim Ibrahim, Jiřı́ Horáček, Tomáš Kašpárek, Cyril Höschl
European Psychiatry March 1, 2015 DOI: 10.1016/s0924-9338(15)30699-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 70 |
| Population | Patients with first-episode schizophrenia spectrum disorders and age-, gender- and education-matched healthy controls |
| Topics | Default mode network |
| Keywords | Schizophrenia object-oriented programming Schizophrenia spectrum Correlation Agency philosophy Christian ministry Audiology Functional connectivity Psychosis |
| Citations | 1 |
| Key findings | The anti-correlated dynamic switching between the default mode and central-executive networks is substantially impaired in first-episode schizophrenia patients during self/other-agency judgment, and the anti-correlation index correlates with task performance. |
Abstract
In this study we sought to explore patterns of neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia spectrum disorders (FES) and healthy controls (HC). Thirty-five FES patients and 35 age-, gender- and education-matched healthy controls. A task-related functional connectivity analysis with the use of independent component analysis (ICA). ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Time-courses of DMN/CEN activity has been analyzed by means of signal power and spectral coherence. There was statistically significant difference in the variable (anti-correlation index, AI) between FES and HC. AI correlated with self-agency judgment task performance in FES. This finding suggests that the main site of pathology in schizophrenia-spectrum disorders may originate in higher-order regulatory mechanisms subserving DMN/CEN orchestration. The study was supported by the IGA Ministry of Health, Czech Republic, grant NT/14291.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |