The MDMA-Neurotoxicity Controversy: Implications for Clinical Research with Novel Psychoactive Drugs
Charles S. Grob, Gary Bravo, Roger Walsh, Mitchell B. Liester
The Journal of Nervous and Mental Disease June 1, 1992 DOI: 10.1097/00005053-199206000-00003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Neurotoxicity Pharmacology Psychoactive drug |
| Citations | 21 |
| Key findings | MDMA produces dose-dependent serotonergic neurotoxicity in animal models, raising concerns about its safety in humans. |
Abstract
GROB, CHARLES S. M.D.; BRAVO, GARY L. M.D.; WALSH, ROGER N. M.D., Ph.D.; LIESTER, MITCHELL B. M.D. Author Information
Comparable studies
Other narrative reviews on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Human Pharmacology of MDMA | 2004 | Review | |
| Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research | 2001 | Review | |
| 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans | 1994 | Review | |
| (±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Studies in Animals | 2000 | Review | |
| Amphetamine toxicities | 2010 | Review |
Citations in the library
Cited by 6
- An Exploration of the History and Controversies Surrounding MDMA and MDA Journal of Psychoactive Drugs September 1, 2001
- Deconstructing Ecstasy: The Politics Of Mdma Research Addiction Research & Theory 2000
- MDMA Is Not Ecstasy: The Production of Pharmaceutical Safety through Documents in Clinical Trials. Medical Anthropology Quarterly March 1, 2021
- Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): Neurodegeneration versus Neuromodulation Pharmaceuticals July 5, 2011
- MDMA misrepresentation: an unresolved problem for Ecstasy users. Journal of Psychoactive Drugs 2002
and 1 more in the library