Microdosing of protein drugs
Clinical Pharmacology & Therapeutics February 1, 2016 DOI: 10.1002/cpt.275 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Microdosing |
| Key findings | Microdosing has been successfully applied to a humanized recombinant protein for the first time, suggesting it may be useful for this class of drugs. |
Abstract
Poor pharmacokinetics (PK) can seriously limit clinical utility. Knowing early whether a new compound is likely to have the desired PK profile at therapeutic doses is therefore important. One approach, microdosing,has shown high success with small molecular weight compounds,despite early skepticism. Vlaminget al.report the first, and successful, clinical application of a microdose of a humanized recombinant protein. But what is the likely success for this class of drugs more generally?