Microdosing: A Critical Assessment of Human Data
Journal of Pharmaceutical Sciences August 23, 2012 DOI: 10.1002/jps.23290 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Microdosing |
| Keywords | Microdose Drug development Pharmacology Pharmacokinetics Medical physics |
| Citations | 51 |
| Key findings | Microdosing can provide pre-IND pharmacokinetic information for early candidate selection, but its predictive value for pharmacologic doses depends on the compound and requires critical assessment of clinical data. |
Abstract
Ultrasensitive analytical methodologies have now made possible the ability to characterize the pharmacokinetics (PK) of compounds following administration to humans of a minute, subpharmacologic dose, a microdose. This has the potential to provide pre-IND information to help in early candidate selection, but only if such information is reasonably predictive of PK at pharmacologic doses. The published clinical data in this area are critically assessed and perspectives drawn. The place of microdosing, alone and coupled with other innovative methodologies, both pre-IND and during clinical development, is considered as a way forward to improve the efficiency and informativeness of drug development.