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Exploring the Interface of Meditation and Psychedelics: A Qualitative Analysis of Experienced Practitioners’ Perspectives on Psychedelic Preparation

Mia Riedel, Rosalind McAlpine, Terje Sparby, Matthew D. Sacchet

PsyArXiv February 8, 2026 preprint DOI: 10.31234/osf.io/p2qcb_v1 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Qualitative study
Sample size 82
Population Experienced meditators who also use psychedelics
Topics Meditation
Key findings Participants described meditation as supporting psychedelic preparation by optimizing pre-psychedelic mindset (openness, adaptability), helping navigate challenges through familiarity, acceptance, and self-regulation, and fostering psychological development and integration. The authors propose that meditation and psychedelics may act synergistically along a continuum of psychological development, and that embedding psychedelic experiences within a broader developmental trajectory may enhance therapeutic potential.

Abstract

Background: Meditation has recently gained attention as a promising tool for enhancing psychedelic preparedness. This exploratory study builds on quantitative work by investigating how experienced meditators who use psychedelics understand meditation’s role in preparation and its influence on different aspects of the psychedelic experience.

Methods: We conducted a reflexive thematic analysis of open-ended responses from participants (N = 82) with experience in both meditation and psychedelic use. Using an inductive, constructionist approach that prioritised meaningfulness over frequency, we sought to identify nuanced, experientially grounded perspectives that may be overlooked by quantitative methods and that can inform future hypothesis generation.

Results: Participants understood meditation as contributing to psychedelic preparation in three primary ways: (1) optimising pre-psychedelic mindset by enhancing openness and adaptability; (2) facilitating the navigation of challenges through familiarity-building, acceptance-based, and self-regulatory strategies; and (3) supporting psychological development by fostering insight and providing a framework for integration and sustained growth.

Conclusions: Findings suggest that meditation and psychedelics may act synergistically along a continuum of psychological development, and that embedding psychedelic experiences within a broader developmental trajectory (such as that offered by meditation) may enhance therapeutic potential. Future work should develop frameworks that integrate models of meditation- and psychedelic-related psychological transformation, particularly regarding advanced meditative development and its endpoints. Such frameworks could inform the creation of safe, synergistic protocols that optimise preparation and improve outcomes at the intersection of third-wave contemplative science and psychedelic research.

Comparable studies

Other qualitative studies on meditation, most cited first.

Study Year Design Participants
The varieties of contemplative experience: A mixed-methods study of meditation-related challenges in Western Buddhists Western Buddhist meditation practitioners and experts in Theravāda, Zen, and Tibetan... 2017 Qualitative study with mixed-methods
The Effects of Mindfulness-based Stress Reduction on Nurse Stress and Burnout Nurses in a hospital system 2004 Implementation study with mixed methods
An exploratory mixed methods study of the acceptability and effectiveness of mindfulness -based cognitive therapy for patients with active depression and anxiety in primary care Primary care patients with recurrent depression or recurrent depression and anxiety 2006 Exploratory mixed methods study n = 13
A qualitative study of mindfulness‐based cognitive therapy for depression Participants in mindfulness-based cognitive therapy in a mental-health context 2001 Qualitative study n = 7
Effortless awareness: using real time neurofeedback to investigate correlates of posterior cingulate cortex activity in meditators' self-report Meditators 2013 Qualitative study using grounded theory methodology

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