Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?
FR Sharp, M Tomitaka, M Bernaudin, S Tomitaka
Trends in Neurosciences June 1, 2001 DOI: 10.1016/s0166-2236(00)01817-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | Inhibition of NMDA receptors on GABAergic thalamic reticular nucleus neurons may activate thalamocortical circuits that produce cortical injury in rodents and psychosis in humans. |
Abstract
Non-competitive NMDA receptor antagonists, such as phencyclidine, ketamine and MK801, produce psychosis in humans. These drugs also produce injury to cingulate-retrosplenial cortex in adult rodents that can be prevented by GABA-receptor agonists and antipsychotics such as haloperidol and clozapine. MK801 injections into anterior thalamus reproduce limbic cortex injury, and GABA-receptor agonist injections into anterior thalamus prevent injury produced by systemic MK801. Inhibition of NMDA receptors on GABAergic thalamic reticular nucleus neurons might activate thalamocortical 'injury' circuits in animals. Pathological activation of thalamocortical circuits might also mediate the psychosis produced by NMDA-receptor antagonists in humans, and might contribute to psychosis in schizophrenia.
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- Psychotomimetic effects of PCP, LSD, and Ecstasy: pharmacological models of schizophrenia? Cambridge University Press eBooks February 4, 2010
- Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology June 2014
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