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The potential role of lysergic acid diethylamide for psychological assisted therapy: A meta‐analysis of randomised controlled trials in healthy volunteers

Hang Li, Yi Zhong, Siyuan Yang, Jiahe Wang, Xiang Li, Jianguo Xu, Heng Gao, Gang Chen

Human Psychopharmacology: Clinical and Experimental November 5, 2021 DOI: 10.1002/hup.2825 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Meta-analysis Randomized Peer reviewed
Population Healthy subjects
Intervention LSD
Topics LSD
Citations 7
Key findings LSD significantly alters subjective drug effects, blood pressure, heart rate, body temperature, and side effects in healthy individuals.

Abstract

In recent years, interest in using lysergic acid diethylamide (LSD) in psychiatric research and corresponding therapy has increased rapidly. In this meta‐analysis, we explored the effects of LSD on healthy subjects with respect to subjective drug effects, blood pressure, heart rate, body temperature and side effects.

Comparable studies

Other systematic reviews and meta-analyses on LSD, most cited first.

Study Year Design Participants
Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials Participants in randomized controlled trials of LSD for alcoholism 2012 Meta-analysis n = 536
Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years Patients from included clinical trials 2016 Systematic review
Default Mode Network Modulation by Psychedelics: A Systematic Review Participants from included studies 2022 Systematic review
Efficacy, tolerability, and safety of serotonergic psychedelics for the management of mood, anxiety, and substance-use disorders: a systematic review of systematic reviews Patients with mood, anxiety, or substance-use disorders, including cancer patients and... 2018 Systematic review of systematic reviews
Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials Patients with psychiatric disorders, primarily alcoholism 2020 Systematic review n = 567

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