The effect of lysergic acid diethylamide, 5-hydroxytryptamine, and related compounds on the liver fluke, Fasciola hepatica
British Journal of Pharmacology and Chemotherapy December 1, 1957 DOI: 10.1111/j.1476-5381.1957.tb00156.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Liver fluke (Fasciola hepatica) |
| Interventions | 5-hydroxytryptamine lysergic acid diethylamide bromolysergic acid diethylamide yohimbine harmine dopamine |
| Dose | very low concentrations |
| Topics | LSD |
| Citations | 51 |
| Key findings | 5-hydroxytryptamine and lysergic acid diethylamide stimulate rhythmical activity in Fasciola hepatica at low concentrations, while certain analogues depress this activity and antagonize the stimulants. |
Abstract
The rhythmical activity of the liver fluke, Fasciola hepatica, was stimulated by 5-hydroxytryptamine and by lysergic acid diethylamide at very low concentrations. The effect was peripheral and was not mediated through the central ganglion. Other amines also stimulated rhythmical activity, the most potent being the indolamines.Bromolysergic acid diethylamide, and other analogues such as yohimbine, harmine, and dopamine depressed rhythmical movement and antagonized the stimulant action of 5-hydroxytryptamine and lysergic acid diethylamide. Evidence which suggests the presence of tryptamine receptors in the trematode is discussed.
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