Plant drugs: Transcending the mescaline biosynthesis.
Vincent Courdavault, Nicolas Papon
Current Biology August 19, 2024 DOI: 10.1016/j.cub.2024.06.061 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Peyote cactus |
| Topics | Mescaline |
| Keywords | Psychedelics Plant biochemistry Natural compounds Conservation biology Medicinal research |
| Citations | 1 |
| Key findings | The complete metabolic pathway for mescaline biosynthesis in peyote has been identified, enabling potential biotechnological production. |
Abstract
Our knowledge of the biosynthesis of medicinal compounds from plants remains limited. A new study has deciphered the complete metabolic pathway leading to the biosynthesis of the psychedelic mescaline in the cactus peyote, suggesting the development of biotechnological strategies for a sustainable supply of this important plant drug.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |
Citations in the library
Cites 3
- United States National Institutes of Health grant funding for psychedelic-assisted therapy clinical trials from 2006-2020. International Journal of Drug Policy 2022
- Elucidation of the mescaline biosynthetic pathway in peyote (Lophophora williamsii). The Plant Journal November 1, 2023
- The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction Molecular Plant June 3, 2024