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Grounded in Biology: Why the Context-Dependency of Psychedelic Drug Effects Means Opportunities, Not Problems for Anthropology and Pharmacology.

Stephan Schleim

Frontiers in Psychiatry May 11, 2022 DOI: 10.3389/fpsyt.2022.906487 (opens in new tab)

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Characteristics Commentary Peer reviewed
Keywords Embodiment Placebo Context-dependency Mind-body problem Psychedelics Psychedelic drugs 4e cognition
Citations 16
Key points Argues that understanding clinically used psychedelics requires attention to context-dependency, examined here through placebo-effect research, and that "moral psychopharmacology" carries multiple meanings best clarified within a broader framework of drug instrumentalization and its associated values. The author distinguishes theoretical, research-oriented, and applied aspects to inform further theoretical, empirical, and ethical discussion.

Abstract

Langlitz and colleagues wrote about clinically used psychedelic drugs and the possibility of a “moral psychopharmacology” earlier in this journal (1). They emphasized the context-dependency of the effects of these substances (e.g., ayahuasca, psilocybin) and the importance of understanding their impact on social and moral cognition, particularly now that there is more research on their possible clinical applications (e.g., to facilitate psychotherapy). In this opinion article, I want to, first, reflect on the context-dependency from the perspective of recent research on placebo effects, and, second, clarify different meanings of “moral psychopharmacology”. The latter will be placed in the context of a broader conceived view on drug instrumentalization (2–4) and different values associated with it (5–7). In the conclusion, I will briefly distinguish aspects primarily relevant to theoretical, research-oriented, or applied perspectives, respectively, to inform further theoretical, empirical, and ethical discussion of these topics.

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