Prolonged delusional state triggered by repeated ingestion of aromatic liquid in a past 5-methoxy-N, N-diisopropyltryptamine abuser.
Yasuko Fuse-Nagase, Toru Nishikawa
Addiction Science & Clinical Practice April 11, 2013 DOI: 10.1186/1940-0640-8-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 30-year-old Japanese man with a history of 5-MeO-DIPT abuse |
| Duration | 2-month ongoing delusions at presentation, 6-month follow-up |
| Topics | 5-MeO-DMT |
| Citations | 14 |
| Key findings | Ingestion of a legal aromatic liquid likely triggered delusional episodes in a patient sensitized by prior 5-MeO-DIPT abuse. |
Abstract
A 30-year-old Japanese man with no previous psychiatric history presented to our facility with delusions, which had been ongoing for 2 months. Upon further interview, he confided that he had a past history of recurrent 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT or "Foxy") abuse, as well as a recent history of recurrent ingestion of a legal aromatic liquid used as a recreational drug. After this episode, his condition improved and he did not follow up at subsequent appointments. However, 6 months later, he suffered a relapse of prolonged delusions after again ingesting a recreational aromatic liquid. An evaluation of the chronological sequence of the patient's condition revealed that ingestion of these aromatic liquids, which can be purchased easily on the Internet, likely triggered the patient's delusional episodes. We speculate that the patient's recurrent abuse of 5-MeO-DIPT caused sensitization (or reverse tolerance), thus prolonging his delusions. Sensitization is the amplification of a response following repeated administrations of a stimulus. 5-MeO-DIPT is a popular drug of abuse, and it is highly probable that a large number of past 5-MeO-DIPT users are currently sensitized. This is an important latent factor underlying subsequent episode of drug-induced psychosis. Psychiatrists should consider the possibility of 5-MeO-DIPT sensitization when evaluating patients with acute psychoses.
Comparable studies
Other case reports and case series on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation. 25-year-old white male | 2005 | Case study | n = 1 |
| Combined intoxication with methylone and 5-MeO-MIPT 27-year-old male patient | 2006 | Case report | n = 1 |
| Sudden death associated with intravenous injection of toad extract. A 24-year-old male | 2009 | Case study | n = 1 |
| 5-Meo-DALT-induced Cyclic Myoclonus (P3.013) A 29-year-old man with history of heroin and marijuana abuse | 2015 | Case report | n = 1 |
| A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder. 31-year-old male military veteran with moderate alcohol use disorder | 2018 | Case study | n = 1 |
Citations in the library
Cited by 8
- The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology August 1, 2015
- Designer drugs: mechanism of action and adverse effects Archives of Toxicology April 1, 2020
- Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish Frontiers in Behavioral Neuroscience July 28, 2017
- Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors. Neuropharmacology February 1, 2015
- Modification of 5-methoxy-N,N-dimethyltryptamine-induced hyperactivity by monoamine oxidase A inhibitor harmaline in mice and the underlying serotonergic mechanisms. Pharmacological Reports June 1, 2016
and 3 more in the library