Pharmacology and Neurotoxicity of 5-MeO-DIPT
Handbook of Neurotoxicity 2021 DOI: 10.1007/978-3-030-71519-9_207-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Adolescent rats |
| Intervention | 5-MeO-DIPT |
| Dose | 2.5 mg/kg × 8 |
| Topics | 5-MeO-DMT |
| Keywords | 5-MEO-Dipt Neurotransmitters Dna damage Adolescence |
| Key points | Repeated intermittent administration of 5-MeO-DIPT during adolescence in rats caused oxidative DNA damage in the cortex, altered neurotransmitter responses, and impaired long-term memory and cognitive flexibility. |
Abstract
Psychedelics are drugs that alter consciousness and affect human psyche. 5-Methoxy- N,N -diisopropyltryptamine (5-MeO-DIPT) emerged in the recreational drug market with the street name “foxy” and has been increasingly used as a substitute for methylenedioxymethamphetamine (MDMA) Methylenedioxymethamphetamine (MDMA) . 5-MeO-DIPT is a competitive inhibitor of the serotonin (5-HT) transporter (SERT), having lower affinity for the dopamine (DA) transporter (DAT) but with high affinity for 5-HT2A, 5-HT2C, and 5-HT1A receptors. As a 5-HT2A receptor agonist, 5-MeO-DIPT produces hallucinogenic effect in mice and rats and increases in vivo release of DA, 5-HT, and glutamate in rat striatum, nucleus accumbens, and frontal cortex. The potent cytotoxic effect of 5-MeO-DIPT was demonstrated in COS-7 cells and in SH-SY5Y and Hep G2 cell lines . Repeated-intermittent 5-MeO-DIPT administration (2.5 mg/kg × 8) in adolescence decreased response to a challenge dose of 5-MeO-DIPT in release of DA, 5-HT, and glutamate in some regions of the rat brain. Furthermore, oxidative DNA damage was observed in the rat cortex. In rats exposed to 5-MeO-DIPT during adolescence, response of DA, 5-HT, and glutamate neurons in the frontal cortex to a challenge dose of MDMA was stronger in comparison with the saline group. 5-MeO-DIPT disturbed animal performance in certain cognitive tasks, while exposure of adolescent rats to repeated-intermittent doses of 5-MeO-DIPT produced impairment of long-term memory or cognitive flexibility in the serial pattern learning test. Abnormalities seen after exposure to 5-MeO-DIPT during adolescence suggest that developmental changes may cause neurological problems in adult life.
Comparable studies
Other preclinical and animal studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Mice and rats | 2006 | Preclinical study | |
| Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Rats and transfected fibroblasts | 1998 | Experimental study | |
| Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat Intact rats and rats depleted of monoamines with reserpine | 1985 | Experimental study |
Citations in the library
Cites 17
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- The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. European Journal of Pharmacology March 22, 2007
- Recreational Use, Analysis and Toxicity of Tryptamines Current Neuropharmacology December 10, 2014
- Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Current Drug Metabolism October 1, 2010
- Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. Journal of Neural Transmission September 12, 2009
and 12 more in the library