Combined intoxication with methylone and 5-MeO-MIPT
Eiji Shimizu, Hiroyuki Watanabe, Takashi Kojima, Hiroko Hagiwara, Mihisa Fujisaki, Ryosuke Miyatake, Kenji Hashimoto, Masaomi Iyo
Progress in Neuro-Psychopharmacology and Biological Psychiatry July 30, 2006 DOI: 10.1016/j.pnpbp.2006.06.012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 27-year-old male patient |
| Topics | 5-MeO-DMT |
| Keywords | Designer drug Mephedrone Hallucinogen Ingestion Pharmacology |
| Citations | 103 |
| Key findings | A single ingestion of a mixture of methylone and 5-MeO-MIPT caused substance intoxication, and the drug's composition differed from what was advertised. |
Abstract
Although preclinical studies suggest that methylone (2-methylamino-1-[3,4-methylenedioxyphenyl]propan-1-one) and 5-MeO-MIPT (5-methoxy-N-methyl,N-isopropyl tryptamine) may have psychostimulant properties, the scientific reports about the clinical effects of these agents are scant. We describe a 27-year-old male patient with substance intoxication after a single ingestion of the mixture of methylone and 5-MeO-MIPT. Though he bought the drug as pure methylone powder via an internet order, our chemical analyses indicated that the drug was composed of about 60% methylone (120 mg) and 38% 5-MeO-MIPT (76 mg). This case report suggests that clinicians should be alert to the possibility of the emergence of methylone or 5-MeO-MIPT intoxication, and substance-related mental disorder may be complicated by combined use of other psychoactive drugs.
Comparable studies
Other case reports and case series on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation. 25-year-old white male | 2005 | Case study | n = 1 |
| Sudden death associated with intravenous injection of toad extract. A 24-year-old male | 2009 | Case study | n = 1 |
| 5-Meo-DALT-induced Cyclic Myoclonus (P3.013) A 29-year-old man with history of heroin and marijuana abuse | 2015 | Case report | n = 1 |
| A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder. 31-year-old male military veteran with moderate alcohol use disorder | 2018 | Case study | n = 1 |
| A Physician’s Attempt to Self-Medicate Bipolar Depression with N,N-Dimethyltryptamine (DMT) A physician with refractory bipolar depression | 2017 | Case study | n = 1 |
Citations in the library
Cited by 14
- The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology August 1, 2015
- Clinical toxicology of newer recreational drugs Clinical Toxicology October 1, 2011
- Recreational Use, Analysis and Toxicity of Tryptamines Current Neuropharmacology December 10, 2014
- Metabolism of designer drugs of abuse: an updated review. Current Drug Metabolism June 1, 2010
- Novel Psychoactive Substances—Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs Frontiers in Psychiatry August 18, 2017
and 9 more in the library
Cites 3
- Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Pharmacology, Biochemistry, and Behavior 2006
- A foxy intoxication. Forensic Science International February 10, 2005
- Cathinone: an investigation of several N-alkyl and methylenedioxy-substituted analogs. Pharmacology, Biochemistry, and Behavior December 1997