The identification of LSD-like hallucinogens using the chronic spinal dog.
William R. Martin, D B Vaupel, M Nozaki, L D Bright
Drug and Alcohol Dependence March 1, 1978 DOI: 10.1016/0376-8716(78)90024-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Chronic spinal dogs |
| Interventions | Psilocin mescaline dimethyltryptamine tryptamine DOM DOB DMA TMA PMA PEA MMDA MDA LSD amphetamine phenoxybenzamine cyproheptadine chlorpromazine pimozide |
| Topics | LSD |
| Citations | 22 |
| Key findings | Psilocin, mescaline, dimethyltryptamine, and tryptamine are LSD-like drugs, while PMA and PEA are predominantly amphetamine-like, and MMDA and MDA have mixed properties with additional unique actions. |
Abstract
The effects of several indoleamines and phenethylamines were studied in the chronic spinal dog and compared with two standard drugs, LSD and amphetamine. In the nontolerant chronic spinal dog, their effects on a variety of physiologic and behavioral functions were measured in untreated dogs, as well as dogs treated with certain antagonists. The effects of the antagonists phenoxybenzamine and cyproheptadine on the various physiologic effects were studied for all drugs. For some idoleamines and phenethylamines, the effects of chlorpromazine and pimozide were also studied. Indoleamines and phenethylamines in the LSD-tolerant chronic spinal dog and their anorexigenic effects in the intact dog were also studied. The results of these studies indicate that psilocin, mescaline, dimethyltryptamine and tryptamine are LSD-like drugs. DOM, DOB, DMA, and TMA are predominantly LSD-like drugs but do have some amphetamine-like action. PMA and PEA are predominantly amphetamine-like drugs with some LSD-like activity. MMDA and MDA have a more complicated pharmacology showing proerties that resemble LSD and amphetamine, but they have other actions which are not shared by either LSD or amphetamine, which suggests they have yet other modes of action.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 11
- Hallucinogenic Amphetamine Selectively Destroys Brain Serotonin Nerve Terminals Science September 6, 1985
- Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain. Biochemical Pharmacology July 15, 1987
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- A pharmacological comparison of 3-methoxy-4,5-methylenedioxyamphetamine and LSD in the dog. Drug and Alcohol Dependence May 1, 1978
- Behavioural Investigations of Psilocybin in Animals 1962-2021: A Scoping Review bioRxiv (Cold Spring Harbor Laboratory) January 5, 2024
and 6 more in the library