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Multiple peripheral inflammatory markers in adolescents with major depressive disorder treated with repeated esketamine infusions: results from a randomized controlled trial.

Xiaofeng Lan, Zitao Wu, Chengyu Wang, Guanxi Liu, Muqin Zhang, Weicheng Li, Zhanjie Luo, Junhao Shen, Ziying Chen, Yuping Ning, Yanling Zhou

J Affect Disord February 23, 2026 DOI: 10.1016/j.jad.2026.121488 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Population Adolescents with major depressive disorder
Intervention Esketamine
Topics Depression Esketamine
Key findings Repeated esketamine infusions were associated with changes in peripheral inflammatory markers in adolescents with major depressive disorder.

Abstract

Multiple peripheral inflammatory markers in adolescents with major depressive disorder treated with repeated esketamine infusions: results from a randomized controlled trial.