Gender Differences in Suicidal and Self-Harming Responses to Esketamine: A Real-World Retrospective Study
Vassilis Martiadis, Fabiola Raffone, Danilo Atripaldi, Serena Testa, Paolo Giunnelli, Rita Cerlino, Manlio Russo, Azzurra Martini, Enrico Pessina, Carlo Ignazio Cattaneo, Domenico de Berardis
Current Neuropharmacology October 20, 2025 DOI: 10.2174/011570159x392347250929114024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preliminary study Peer reviewed |
|---|---|
| Population | People with treatment-resistant depression |
| Intervention | Esketamine |
| Topics | Esketamine |
| Citations | 21 |
| Key points | Esketamine rapidly improved suicidality and depression in treatment-resistant depression, with preliminary evidence of gender-specific responses. |
Abstract
Esketamine rapidly improved suicidality and depression in TRD, with preliminary evidence suggesting gender-specific responses, and highlighting the importance of tailored interventions to maximize outcomes. Further research is needed to confirm these differences, explore the long-term effects, and understand the underlying mechanisms.