Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system
Jakub Schimmelpfennig, Kamila Jankowiak-Siuda
Neuropsychiatria i Neuropsychologia 2023 DOI: 10.5114/nan.2023.129068 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | 5-MeO-DMT DMT |
| Keywords | Neuropsychiatry Neuropsychology Perspective graphical Cognition |
| Citations | 1 |
| Key findings | Endogenous DMT exhibits unique biological properties, including interactions with sigma-1 and trace amine-associated receptors, that may contribute to neuroplasticity, neuroprotection, and modulation of consciousness, with potential implications for treating neurodegenerative and psychiatric disorders. |
Abstract
AMA Schimmelpfennig J, Jankowiak-Siuda K. Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2023;18(1):1-10. doi:10.5114/nan.2023.129068. APA Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023). Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, 18(1), 1-10. https://doi.org/10.5114/nan.2023.129068 Chicago Schimmelpfennig, Jakub, and Kamila Jankowiak-Siuda. 2023. "Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system". Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology 18 (1): 1-10. doi:10.5114/nan.2023.129068. Harvard Schimmelpfennig, J., and Jankowiak-Siuda, K. (2023). Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, 18(1), pp.1-10. https://doi.org/10.5114/nan.2023.129068 MLA Schimmelpfennig, Jakub et al. "Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system." Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, vol. 18, no. 1, 2023, pp. 1-10. doi:10.5114/nan.2023.129068. Vancouver Schimmelpfennig J, Jankowiak-Siuda K. Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2023;18(1):1-10. doi:10.5114/nan.2023.129068.
Comparable studies
Other narrative reviews on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neuropharmacology of N,N-dimethyltryptamine | 2016 | Review | |
| N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function Humans and animals (general) | 2018 | Review | |
| Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Humans (pharmacokinetics) | 2010 | Review | |
| Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT) | 2018 | Review | |
| A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity. | 2013 | Review |
Citations in the library
Cited by 2
- N, N-dimethyltryptamine (DMT) in rodent brain: Concentrations, distribution, and recent pharmacological data. Progress in Neuro-Psychopharmacology and Biological Psychiatry March 20, 2025
- Antinociceptive effect of N,N-dimethyltryptamine (DMT) involving serotonergic, opioidergic, cannabinoidergic, and nitrergic systems in PGE2-induced hyperalgesia in rats Journal of Pain Research and Management February 14, 2026
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- REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics Pharmacological Reviews June 20, 2019
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects. ACS Pharmacology & Translational Science December 10, 2020
- Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. European Neuropsychopharmacology May 20, 2016
- The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects ACS Pharmacology & Translational Science December 10, 2020
and 54 more in the library