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Antinociceptive effect of N,N-dimethyltryptamine (DMT) involving serotonergic, opioidergic, cannabinoidergic, and nitrergic systems in PGE2-induced hyperalgesia in rats

Flávia C.S. Fonseca, Daniel P.D. Machado, André D. Cavalcante, Andrea C. Perez, Thiago R.L. Romero, Igor D.G. Duarte

Journal of Pain Research and Management February 14, 2026 DOI: 10.46439/painresearch.2.015 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Review Longitudinal Cross-sectional Peer reviewed
Topics Anxiety 5-MeO-DMT DMT Serotonin
Keywords Anxiolytic Hallucinogen Hyperalgesia Human studies Nociception Central nervous system Depression economics Animal studies Analgesic Perspective graphical Neuroinflammation Neuropharmacology Endogeny
Key findings Argues that ayahuasca and its constituent DMT show potential antidepressant, anxiolytic, and analgesic effects based on preclinical and clinical evidence, with mechanisms involving serotonergic, opioid, and cannabinoid pathways. Notes safety concerns and the need for more rigorous studies.

Abstract

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