Psilocybin’s Effects on Headache Frequency are Not Related to Acute Psychedelic Effects or Measures of Mental Health: Secondary Analysis of Clinical Trials in Migraine and Cluster Headache (P7-12.001)
Emmanuelle A. D. Schindler, Christopher Gottschalk, Deepak Cyril D’souza
Neurology April 7, 2025 DOI: 10.1212/wnl.0000000000210945 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational analysis of clinical trial data Peer reviewed |
|---|---|
| Population | Patients with migraine or cluster headache in clinical trials of psilocybin |
| Intervention | Psilocybin |
| Topics | Psilocybin |
| Keywords | Migraine Cluster headache Clinical trial Anesthesia Hallucinogen |
| Citations | 2 |
| Key findings | Acute psychedelic effects and mental health improvements were not associated with reduced headache frequency in psilocybin trials for migraine and cluster headache. |
Abstract
To examine the relationship of acute psychedelic effects and measures of mental health with headache frequency in clinical trials of psilocybin in migraine and cluster headache.