Ketamine changes the local resting-state functional properties of anesthetized-monkey brain.
Jia-Sheng Rao, Zuxiang Liu, Can Zhao, Rui-Han Wei, Wen Zhao, Peng-Yu Tian, Xia Zhou, Zhao-Yang Yang, Xiao-Guang Li
Magnetic resonance imaging November 2017 DOI: 10.1016/j.mri.2017.07.025 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study (pre-post within-subject rs-fMRI comparison) Peer reviewed |
|---|---|
| Sample size | 7 |
| Population | Adult rhesus monkeys |
| Intervention | Ketamine |
| Measures | fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo) |
| Topics | Ketamine Esketamine |
| Keywords | Local functional properties Resting-state Rhesus monkey |
| Key findings | In seven adult rhesus monkeys, single-dose ketamine increased fALFF in the prefrontal cortex (p=0.046), caudate nucleus (left p=0.018; right p=0.025), and putamen (p=0.020), and increased ReHo in the nucleus accumbens (p=0.049), caudate nucleus (p=0.037), and hippocampus (p=0.025), while decreasing ReHo in the prefrontal cortex (p<0.05). The authors conclude that single-dose ketamine alters the regional intensity and synchrony of resting-state brain activity in primates. |
Abstract
Ketamine is a well-known anesthetic. 'Recreational' use of ketamine common induces psychosis-like symptoms and cognitive impairments. The acute and chronic effects of ketamine on relevant brain circuits have been studied, but the effects of single-dose ketamine administration on the local resting-state functional properties of the brain remain unknown. In this study, we aimed to assess the effects of single-dose ketamine administration on the brain local intrinsic properties. We used resting-state functional magnetic resonance imaging (rs-fMRI) to explore the ketamine-induced alterations of brain intrinsic properties. Seven adult rhesus monkeys were imaged with rs-fMRI to examine the fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) in the brain before and after ketamine injection. Paired comparisons were used to detect the significantly altered regions. Results showed that the fALFF of the prefrontal cortex (p=0.046), caudate nucleus (left side, p=0.018; right side, p=0.025), and putamen (p=0.020) in post-injection stage significantly increased compared with those in pre-injection period. The ReHo of nucleus accumbens (p=0.049), caudate nucleus (p=0.037), and hippocampus (p=0.025) increased after ketamine injection, but that of prefrontal cortex decreased (p<0.05). These findings demonstrated that single-dose ketamine administration can change the regional intensity and synchronism of brain activity, thereby providing evidence of ketamine-induced abnormal resting-state functional properties in primates. This evidence may help further elucidate the effects of ketamine on the cerebral resting status.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cited by 2
Cites 5
- Ketamine Decreases Resting State Functional Network Connectivity in Healthy Subjects: Implications for Antidepressant Drug Action PLoS One September 24, 2012
- NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia Proceedings of the National Academy of Sciences September 25, 2012
- Brain damages in ketamine addicts as revealed by magnetic resonance imaging Frontiers in Neuroanatomy May 22, 2014
- Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology Molecular Psychiatry January 3, 2012
- Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study. Addiction January 2010