Khat and mushrooms associated with psychosis
Roman J Nielen, Frank Mma van der Heijden, S. Tuinier, W.m.a. Verhoeven
The World Journal of Biological Psychiatry 2004 DOI: 10.1080/15622970410029908 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case series with literature review Case report Peer reviewed |
|---|---|
| Sample size | 4 |
| Population | Male patients with khat- or psilocybin-induced psychosis |
| Keywords | Psychosis Traditional medicine |
| Citations | 42 |
| Key findings | Khat- and psilocybin-induced psychoses can resolve without treatment or with short-term antipsychotic medication, with no somatic complications, but require careful diagnosis and attention to social consequences. |
Abstract
Objective: This paper describes two cases with khat- and two with psilocybin-induced psychoses and draws attention to the medical and social consequences of the use of these drugs.
Method: Two male patients are presented who developed relapsing and short-lasting psychotic episodes after chewing kath leaves. In addition, two male patients are reported who showed an acute exacerbation of psychosis after ingestion of psilocybin mushrooms. In addition, a review of the literature is presented.
Results: The khat-induced psychotic symptoms disappeared without any treatment within one week. One of the patients with a psilocybin-induced psychosis was treated with risperidone. In the other, symptomatology subsided in a few days. No somatic medical complications occurred.
Conclusion: Adequate psychiatric diagnosis and treatment of the psychoses and the negative social consequences of the use of these drugs are stressed as well as the delineation from functional psychoses in cases of chronic use. The latter applies to patients with psychiatric comorbidity in particular.
Citations in the library
Cited by 11
- Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences Journal of Psychopharmacology August 31, 2016
- Harm potential of magic mushroom use: a review. Regulatory toxicology and pharmacology : RTP April 1, 2011
- Case analysis of long-term negative psychological responses to psychedelics Scientific Reports September 25, 2023
- Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development. Fungal biology April 1, 2022
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
and 6 more in the library
Cites 4
- Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Neuroreport December 1, 1998
- Über den Gebrauch psychoaktiver Pilze als Rauschmittel Fortschritte der Neurologie · Psychiatrie December 1, 2001
- 5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man--a PET study with [11C]raclopride. Neuropsychopharmacology May 1999
- Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex. Psychopharmacology 1989