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Characteristics
Randomized controlled trial
Peer reviewed
Population
Patients undergoing gynecologic malignancy laparotomy
Intervention
Esketamine
Dose
low-dose
Topics
Ketamine
Esketamine
Keywords
Laparotomy
Randomized controlled trial
Anesthesia
Surgery
Gynecologic oncology
Gynecologic surgical procedures
Analgesic
Postoperative pain
Patient-controlled analgesia
Citations
1
Post-publication review
1 comment on PubPeer (opens in new tab)
· last active October 2025
Key findings
Intraoperative low-dose esketamine failed to further improve the QoR-40 score after gynecologic malignancy laparotomy when used as part of a multimodal analgesic regimen.
Abstract
Intraoperative low-dose esketamine failed to further improve the QoR-40 score after gynecologic malignancy laparotomy when used as part of a multimodal analgesic regimen. Further research is needed to explore the optimal dosage and indications of esketamine in this patient population.
Comparable studies
Other randomized controlled trials on
esketamine , most cited first.
Study
Year
Design
Participants
Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study
Adults with moderate to severe nonpsychotic depression and a history of nonresponse to...
2019
Phase 3, double-blind, active-controlled, multicenter randomized controlled trial
n = 227
Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression
Adults with treatment-resistant depression who achieved stable remission or stable...
2019
Phase 3, multicenter, double-blind, randomized withdrawal study
n = 297
Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression
Adults with DSM-IV-TR diagnosis of major depressive disorder and history of inadequate...
2017
Phase 2, double-blind, doubly randomized, delayed-start, placebo-controlled study
n = 67
Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study
Depressed patients at imminent risk for suicide
2018
Randomized controlled trial
n = 68
Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)
Adults with moderate-to-severe depression and nonresponse to at least two...
2019
Randomized controlled trial
n = 346
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