Mining the Mind: Linear Discriminant Analysis of MEG source reconstruction time series supports dynamic changes in deep brain regions during meditation sessions
Daniela Calvetti, B. Johnson, Annalisa Pascarella, Francesca Pitolli, Erkki Somersalo, Barbara Vantaggi
arXiv Preprint Archive January 29, 2021 preprint
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Longitudinal |
|---|---|
| Population | Experienced Buddhist monks |
| Intervention | Open monitoring (Vipassana) meditation |
| Topics | Buddhism Meditation |
| Keywords | Q-bio.nc Cs.na Math.na Brain-imaging |
| Key findings | MEG data from experienced Buddhist monks can be used to distinguish between focused attention meditation, open monitoring meditation, and resting state, with key separating brain regions including the cingulate cortex, insular cortex, and subcortical structures like the accumbens, caudate, putamen, thalamus, and amygdalae. |
Abstract
Meditation practices have been claimed to have a positive effect on the regulation of mood and emotion for quite some time by practitioners, and in recent times there has been a sustained effort to provide a more precise description of the changes induced by meditation on human brain. Longitudinal studies have reported morphological changes in cortical thickness and volume in selected brain regions due to meditation practice, which is interpreted as evidence for effectiveness of it beyond the subjective self reporting. Evidence based on real time monitoring of meditating brain by functional imaging modalities such as MEG or EEG remains a challenge. In this article we consider MEG data collected during meditation sessions of experienced Buddhist monks practicing focused attention (Samatha) and open monitoring (Vipassana) meditation, contrasted by resting state with eyes closed. The MEG data is first mapped to time series of brain activity averaged over brain regions corresponding to a standard Destrieux brain atlas, and further by bootstrapping and spectral analysis to data matrices representing a random sample of power spectral densities over bandwidths corresponding to $\alpha$, $\beta$, $\gamma$, and $\theta$ bands in the spectral range. We demonstrate using linear discriminant analysis (LDA) that the samples corresponding to different meditative or resting states contain enough fingerprints of the brain state to allow a separation between different states, and we identify the brain regions that appear to contribute to the separation. Our findings suggest that cingulate cortex, insular cortex and some of the internal structures, most notably accumbens, caudate and putamen nuclei, thalamus and amygdalae stand out as separating regions, which seems to correlate well with earlier findings based on longitudinal studies.
Comparable studies
Other observational and cohort studies on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Using Self-Report Assessment Methods to Explore Facets of Mindfulness Undergraduate students | 2006 | Observational cohort | |
| Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders Patients with generalized anxiety disorder or panic disorder with or without agoraphobia | 1992 | Observational cohort | n = 22 |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| Long-term meditators self-induce high-amplitude gamma synchrony during mental practice Long-term Buddhist practitioners and controls | 2004 | Observational cohort |