THE EFFECT OF AN ECTOSYLVIAN EPILEPTOGENIC FOCUS INDUCED BY TOPICAL APPLICATION OF MESCALINE ON NITROGENOUS COMPOUNDS IN THE NEOCORTEX OF CAT
G Badiu, N Mison-Crighel
Journal of Neurochemistry November 1, 1966 DOI: 10.1111/j.1471-4159.1966.tb04280.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cat neocortex |
| Intervention | mescaline |
| Duration | 30 minutes |
| Topics | Mescaline |
| Keywords | Neocortex Focus optics Cerebral cortex Cortex anatomy Nitrogen Pharmacology Organic chemistry Hallucinogen |
| Citations | 4 |
| Key findings | Mescaline application to the neocortex caused widespread changes in nitrogenous compounds, including increased ammonia and decreased free amide and protein nitrogen, both locally at the focus and throughout the cerebral cortex. |
Abstract
SUMMARY An cctosylvian spiking focus, induced by topical application of mescaline, brought about changes in nitrogenous compounds not only in the focus but throughout the cerebral cortex. Prior to the onset of the spiking focus, 2 min after mescaline application, ammonia levels increased significantly in all neocortical areas, especially at the focus and homolateral marginal gyrus; free amide nitrogen decreased and non‐protein nitrogen increased throughout the cortex. During the development of the focus–at 30 min–the ammonia level still remained high, with a tendency to decrease, and free amide nitrogen was decreased in all neocortical areas. A decrease in‘protein nitrogen’in marginal gyri, on either side and in lipid nitrogen in the epileptical focus as well as in both marginal gyri was also noted.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |