Attenuation of the disruptive effects of (+/-)3,4-methylene dioxymethamphetamine (MDMA) on delayed matching-to-sample performance in the rat.
David N. Harper, Maree Hunt, Susan Schenk
Behavioral Neuroscience 2006 DOI: 10.1037/0735-7044.120.1.201 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | MDMA |
| Topics | MDMA |
| Keywords | Confusion Limiting Audiology Developmental psychology |
| Citations | 26 |
| Post-publication review | 1 comment on PubPeer (opens in new tab) · last active September 2016 |
| Key findings | A 15-second intertrial interval ameliorated the disruptive effects of MDMA on trial performance compared to a 5-second interval. |
Abstract
Recent evidence suggests that the disruptive effects of acute exposure to (+/-)3,4-methylene dioxymethamphetamine (MDMA) on memory performance may be the result of increased confusion between previous-trial and current-trial events. The current study tested this hypothesis by examining the effects of MDMA on performance of rats in a delayed matching-to-sample procedure when the length of the intertrial interval (ITI) was altered. Consistent with the possibility that limiting the conditions under which responses made on a previous trial would interfere with current-trial choice, a 15-s ITI ameliorated the disruptive effects caused by MDMA on trial performance when the ITI was 5 s. Therefore, the disruptive effects of MDMA on memory can be attenuated by methods that separate current-trial "to-be-remembered" events from previous-trial events.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 7
- Methylenedioxymethamphetamine (MDMA) in Psychiatry Journal of Clinical Psychopharmacology October 10, 2018
- MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy. Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2024
- Acute MDMA Exposure Causes Reference Memory Impairments in the Radial Arm Maze with Rats The Open Addiction Journal March 29, 2011
- An Increase in Post-Reinforcer ‘Preference Pulses’ Underlies an MDMAInduced Increase in Reinforcer Sensitivity Following Acute but Not Chronic Exposure The Open Addiction Journal March 29, 2011
- Behavioural and Neurochemical Effects of Acute (±) 3,4 methylenedioxymethamphetamine (MDMA) in the Dopamine D1 Receptor Mutant Rat 2016
and 2 more in the library
Cites 6
- Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Journal of Neurology, Neurosurgery, and Psychiatry June 1, 2000
- Memory impairment in abstinent MDMA (“Ecstasy”) users: A longitudinal investigation Neurology April 10, 2001
- Subjective ratings of prospective memory deficits in MDMA (‘ecstasy’) users Human Psychopharmacology: Clinical and Experimental May 9, 2001
- MDMA and memory: the acute and chronic effects of MDMA in pigeons performing under a delayed-matching-to-sample procedure Psychopharmacology February 1, 1993
- Cognitive performance and serotonergic function in users of ecstasy. Psychopharmacology January 1, 2001
and 1 more in the library