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Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers

Glenn Dumont, E. Wezenberg, M. M. G. J. Valkenberg, C.a.j. de Jong, Jan K. Buitelaar, Joop van Gerven, Robbert J. Verkes

Psychopharmacology February 28, 2008 DOI: 10.1007/s00213-007-1056-9 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Crossover study Peer reviewed
Interventions MDMA ethanol
Topics MDMA
Keywords Hallucinogen Psychomotor learning Placebo Ethanol Drug Crossover study Anesthesia Neuropsychology Pharmacology Cognition
Citations 50
Key points Co-administration of MDMA and ethanol did not exacerbate the effects of either drug alone, but all drug conditions significantly impaired cognitive function.

Abstract

Co-administration of MDMA and ethanol did not exacerbate the effects of either drug alone. Although the impairment of performance by all drug conditions was relatively moderate, all induced significant impairment of cognitive function.

Comparable studies

Other randomized controlled trials on MDMA, most cited first.

Study Year Design Participants
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Patients with severe PTSD, including those with comorbidities such as dissociation,... 2021 Randomized controlled trial n = 90
The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. Patients with chronic post-traumatic stress disorder refractory to both psychotherapy... 2010 Randomized controlled trial n = 20
3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial. Military veterans and first responders aged 18 or older with chronic PTSD lasting 6... 2018 Randomized, double-blind, dose-response, phase 2 clinical trial n = 26
A randomized, controlled pilot study of MDMA (±3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD) Patients with treatment-resistant PTSD 2012 Randomized controlled trial n = 12
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial. Adults with moderate to severe post-traumatic stress disorder 2023 Randomized controlled trial n = 104

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