PRECLINICAL STUDY: Acquisition and reinstatement of MDMA‐induced conditioned place preference in mice pre‐treated with MDMA or cocaine during adolescence
Manuel Daza‐losada, Marta Rodríguez‐arias, María A. Aguilar, José Miñarro
Addiction Biology September 8, 2009 DOI: 10.1111/j.1369-1600.2009.00173.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Adolescent mice |
| Interventions | MDMA cocaine |
| Dose | 10 mg/kg MDMA, 25 mg/kg cocaine, 10 mg/kg MDMA plus 25 mg/kg cocaine |
| Duration | 3-day pre-treatment (PD28-30), conditioned place preference procedure initiated at PD52 |
| Topics | MDMA |
| Citations | 37 |
| Key findings | Adolescent exposure to MDMA or cocaine induces long-lasting changes that alter adult responses to MDMA, including altered conditioned place preference acquisition, extinction, and reinstatement. |
Abstract
ABSTRACT Those who take ecstasy are more likely to consume other drugs than non‐users with cocaine abuse being reported by 75.5% of high school student MDMA (± 3,4‐methylenedioxymetamphetamine hydrochloride) users. The aim of this work was to evaluate the effects of exposure during adolescence to MDMA, cocaine or to both drugs on the MDMA‐induced conditioned place preference (CPP) in adult mice. Animals received two daily administrations of saline, 10 mg/kg of MDMA, 25 mg/kg of cocaine or 10 mg/kg of MDMA plus 25 mg/kg of cocaine over 3 days (from PD28 to 30). Three weeks after pre‐treatment, the MDMA‐induced CPP procedure was initiated (PD52). Acquisition of CPP was induced with a sub‐threshold dose of MDMA (1.25 mg/kg) only in animals treated during adolescence with MDMA alone. Preference was established in all the groups after conditioning with 10 mg/kg of MDMA, while the time required to achieve extinction was longer in those pre‐treated with cocaine or MDMA alone (46 and 28 sessions, respectively). Moreover, preference was reinstated with progressively lower priming doses of MDMA in mice pre‐treated with MDMA or cocaine alone. These results demonstrate that early exposure to MDMA or cocaine induces long‐lasting changes that last until adulthood and modify the response of animals to MDMA.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 11
- Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine ACS Chemical Neuroscience July 12, 2018
- Involvement of NMDA glutamate receptors in the acquisition and reinstatement of the conditioned place preference induced by MDMA Behavioural Pharmacology May 14, 2015
- Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice Behavioural Pharmacology September 1, 2014
- Adolescent pre‐exposure to ethanol and 3,4‐methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding effects of MDMA and drug‐induced reinstatement Addiction Biology October 13, 2011
- Longitudinal Examination of Learning and Memory in Rats Following Adolescent Exposure to 3,4-Methylenedioxymethamphetamine or 5-Methoxy-N,N-Diisopropyltryptamine Journal of Behavioral and Brain Science 2017
and 6 more in the library
Cites 10
- Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice British Journal of Pharmacology October 29, 2003
- Enhancement of conditioned place preference response to cocaine in rats following subchronic administration of 3,4-methylenedioxymethamphetamine (MDMA) Synapse February 1, 2000
- Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addiction Biology April 2009
- Age-dependent differences in sensitivity and sensitization to cannabinoids and 'club drugs' in male adolescent and adult rats. Addiction Biology September 2008
- Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats. Drug and Alcohol Dependence August 1, 2008
and 5 more in the library